Oxygen Perfusion in the Brain
Oxygen Perfusion in the Brain Heading link
High-Resolution Computation of Oxygen Perfusion in the Cerebral Cortex
Convection of blood oxygen in the vascular network is coupled by mass transport across the blood-brain barrier to diffusion and metabolic consumption of tissue oxygen in a unified computational framework that eschews traditional fitted finite element meshes. Blood flow networks are represented as voxel masks in 3D space for the purpose of mapping oxygen transfer points between 1D vascular and 3D tissue domains at a user prescribed level of spatial resolution. Domain decomposition and fast Fourier preconditioning techniques take advantage of the simplified matrix structures of the transport equations to compute steady-state oxygen perfusion at high speed at resolutions approaching the capillary scale for networks of anatomically accurate complexity.