Andreas Linninger, PhD

Mission

Cerebral hemodynamics and metabolism: Explore fundamental mechanisms of cerebral blood flow and metabolism in the brain to explain the control of cerebral blood flow as a function of brain activity in normal and disease states such as stroke. Our work aims to quantify transport and pharmacokinetic mechanisms using advanced imaging modalities in combination with computational techniques. Our lab conducts experiments on cell culture and animal models and performs non-invasive imaging on human subjects with magnetic resonance imaging and digital subtraction angiography.

Drug Delivery: We explore drug administration techniques to the central nervous system via convection enhancement, electromagnetic guidance of nanoparticles as well as intrathecal drug delivery. To complement experiments, we use computational methods to study quantitative dose-response relationship for optimal drug delivery.

Education: Train bioengineers and medical researchers in intracranial dynamics, pharmacokinetics and metabolism of the central nervous system.

Hydrocephalus: Our lab studies the causes and effects of hydrocephalus. We investigate the role of brain aquaporins in water clearance during pathological processes. We develop and test new pharmacological treatment options based on new insights about molecular water transport mechanism in the brain.