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Andreas Linninger, PhD


Drug Delivery: We explore drug administration techniques to the central nervous system via convection enhancement, electromagnetic guidance of nanoparticles as well as intrathecal drug delivery. To complement experiments, we use computational methods to study quantitative dose-response relationship for optimal drug delivery.

Cerebral hemodynamics and metabolism: Explore fundamental mechanisms of cerebral blood flow and metabolism in the brain to explain the control of cerebral blood flow as a function of brain activity in normal and disease states such as stroke. Our work aims to quantify transport and pharmacokinetic mechanisms using advanced imaging modalities in combination with computational techniques. Our lab conducts experiments on cell culture and animal models and performs non-invasive imaging on human subjects with magnetic resonance imaging and digital subtraction angiography.

Oxygen perfusion in the cerebral cortex: Our access to high-quality models of the cerebral vasculature enables the simulation of oxygen transport within blood vessels and through the blood-brain barrier into the extravascular tissue space. These extremely complex geometries are represented using a unified graph theoretical framework that allows the full coupling of vascular and tissue domains and their dominant modes of transport.

Education: Train bioengineers and medical researchers in intracranial dynamics, pharmacokinetics and metabolism of the central nervous system.

Our Areas of Research